Journal article
Monogenic and polygenic determinants of sarcoma risk: an international genetic study
ML Ballinger, DL Goode, I Ray-Coquard, PA James, G Mitchell, E Niedermayr, A Puri, JD Schiffman, GS Dite, A Cipponi, RG Maki, AS Brohl, O Myklebost, EW Stratford, S Lorenz, SM Ahn, JH Ahn, JE Kim, S Shanley, V Beshay Show all
Lancet Oncology | Published : 2016
Abstract
Background Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately affect the young. Outside rare syndromes, the nature, extent, and clinical significance of their genetic origins are not known. We aimed to investigate the genetic basis for bone and soft-tissue sarcoma seen in routine clinical practice. Methods In this genetic study, we included 1162 patients with sarcoma from four cohorts (the International Sarcoma Kindred Study [ISKS], 966 probands; Project GENESIS, 48 probands; Asan Bio-Resource Center, 138 probands; and kConFab, ten probands), who were older than 15 years at the time of consent and had a histologically confirmed diagnosis of sarcoma, recruited fro..
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Grants
Awarded by Pediatric Cancer Foundation
Funding Acknowledgements
Rainbows for Kate Foundation, Johanna Sewell Research Foundation, Australian National Health and Medical Research Council, Cancer Australia, Sarcoma UK, National Cancer Institute, Liddy Shriver Sarcoma Initiative.